منابع مشابه
Entamoeba bangladeshi nov. sp., Bangladesh
Table. Sequencing outcomes for remaining 13 of 15 samples that were negative by PCR for Entamoeba histolytica, E. dispar, and E. moshkovskii and that were not the novel species E. bangladeshi Specimen no. Sequencing outcome 1 97% identity to E. bangladeshi, but insufficient sequence length led to ambiguous assignment, conservatively removed from further analysis 2 No priming upon sequencing 3 N...
متن کاملStructural Insight into DFMO Resistant Ornithine Decarboxylase from Entamoeba histolytica: An Inkling to Adaptive Evolution
BACKGROUND Polyamine biosynthetic pathway is a validated therapeutic target for large number of infectious diseases including cancer, giardiasis and African sleeping sickness, etc. α-Difluoromethylornithine (DFMO), a potent drug used for the treatment of African sleeping sickness is an irreversible inhibitor of ornithine decarboxylase (ODC), the first rate limiting enzyme of polyamine biosynthe...
متن کاملAmebiasis and mucosal IgA antibody against the Entamoeba histolytica adherence lectin in Bangladeshi children.
Amebiasis is the third leading parasitic cause of death worldwide, and it is not known whether immunity is acquired from a previous infection. An investigation was done to determine whether protection from intestinal infection correlated with mucosal or systemic antibody responses to the Entamoeba histolytica GalNAc adherence lectin. E. histolytica colonization was present in 0% (0/64) of child...
متن کاملInfluence of human leukocyte antigen class II alleles on susceptibility to Entamoeba histolytica infection in Bangladeshi children.
BACKGROUND The association of antibody responses with both innate and acquired immunity to amebiasis indicate that CD4+ T cells play a role in protection against Entamoeba histolytica infection. To test this hypothesis, we compared the genotype frequencies of human leukocyte antigen (HLA) class II alleles in a cohort of Bangladeshi children intensively monitored for E. histolytica infection for...
متن کاملEntamoeba histolytica Trophozoites Induce an Inflammatory Cytokine
Infection with the protozoan parasite Entamoeba histolytica results in a high mortality worldwide. To initiate infection, E. histolytica trophozoites in the bowel lumen penetrate the epithelium, and cause extensive lysis of host cells. The acute amebic lesions in animal models are characterized by infiltration with inflammatory cells, particularly neutrophils. The acute host response is likely ...
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ژورنال
عنوان ژورنال: Tropical Parasitology
سال: 2014
ISSN: 2229-5070
DOI: 10.4103/2229-5070.138536